منابع مشابه
Bmi1-positive cells in the lingual epithelium could serve as cancer stem cells in tongue cancer
We recently reported that the polycomb complex protein Bmi1 is a marker for lingual epithelial stem cells (LESCs), which are involved in the long-term maintenance of lingual epithelial tissue in the physiological state. However, the precise role of LESCs in generating tongue tumors and Bmi1-positive cell lineage dynamics in tongue cancers are unclear. Here, using a mouse model of chemically (4-...
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Using in-vivo lineage tracing data we quantified clonal expansion as well as proliferation and differentiation of the Lgr5-positive stem cell population in pyloric gastric glands. Fitting clone expansion models, we estimated that there are five effective Lgr5-positive cells able to give rise to monoclonal glands by replacing each other following a pattern of neutral drift dynamics. This analysi...
متن کاملEvidence for stem-cell niches in the tracheal epithelium.
It is generally important to elucidate airway epithelial cell lineages and to identify multipotent progenitors as targets for gene therapy. Stem (S) cells are typically present in specialized compartments spatially proximal to their differentiated progeny, but an equivalent paradigm has not been demonstrated in the airway. We discovered a distinct population of cells displaying high levels of k...
متن کاملThe gustatory competence of the lingual epithelium requires neonatal innervation.
The rat vallate papilla is bilaterally innervated by the IXth nerve whose axons are required for the normal development of its several hundred taste buds. Temporary denervation during the developmental sensitive period for taste buds prevented most vallate taste buds from forming. Specifically, removing one IXth nerve and crushing the other in 3 day old neonates eliminated axons from the vallat...
متن کاملSynchronous lingual granular cell tumor and squamous cell carcinoma (case report)
Synchronous lingual granular cell tumor and squamous cell carcinoma (case report) Dr. D. Sadri* *-Assistant Professor of Oral & Maxillofacial Pathology Dept. – Faculty of Dentistry – Tehran Islamic Azad University. Introduction: For the first time, Abrikossof described granular cell tumor in 1926. It was firstly believed that this tumor originated from skeletal muscle but using electron microsc...
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ژورنال
عنوان ژورنال: The Journal of Kansai Medical University
سال: 2015
ISSN: 0022-8400,2185-3851
DOI: 10.5361/jkmu.66.1